Pharmacological properties Duac Gel:
Pharmacodynamics. Clindamycin is an antibiotic linkozamidnym with bacteriostatic action against Gram-positive aerobic microorganisms and a wide range of anaerobic bacteria. Lincosamides such as clindamycin bind to the 23S subunit of bacterial ribosomes and inhibit early stages of protein synthesis. The action of clindamycin is predominantly bacteriostatic although high concentrations may have a slow bactericidal action against sensitive strains.
Although clindamycin phosphate is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterial active clindamycin. Activity of clindamycin demonstrated clinically in the treatment of comedones in patients with acne, at levels sufficient for drug activity against most strains of Propionibacteium acnes. Clindamycin in vivo inhibits all tested culture Propionibacteium acnes (MIC 0,4 mg / ml). After application of clindamycin percentage of free fatty acids on the surface of the skin decreased from approximately 14 to 1%.
Benzoyl peroxide has a mild keratolytic effect against comedones at all stages of their development. It is an oxidizing agent with bactericidal activity against Propionibacteium acnes, which is the cause of acne vulgaris. In addition, he is sebostatikom that prevents excessive production of sebum associated with acne.
Adding benzoyl peroxide reduces the potential for the emergence of organisms resistant to clindamycin.
Pharmacokinetics. Absorption through the skin at a minimum of clindamycin. The presence of benzoyl peroxide in the composition of the drug has no effect on the absorption of clindamycin. A study with radiomarkirovaniem showed that absorption of benzoyl peroxide through the skin is possible only after its conversion to benzoic acid. Benzoic acid is conjugated mainly with the formation of hippuric acid which is excreted by the kidneys.
INDICATIONS Duac Gel:
topical treatment of acne (acne vulgaris).
APPLICATION Duac Gel:
for external use only.
Adults and children over the age of 12 years.
Duac Gel applied once a day in the evening to the affected areas after thorough cleansing and rinsing with water. Apply gently with a thin layer to complete absorption.
Treatment with Duac Gel should not exceed 12 weeks of continuous use.
CONTRAINDICATIONS Duac Gel:
hypersensitivity to the drug and lincomycin. Age 12 years. Lactation.
SIDE EFFECTS Duac Gel:
erythema, skin peeling, dryness and itching at the application of the drug, the aggravation of the disease. In rare cases there may be paresthesia and dermatitis. Prolonged use may Duac Gel development of resistance of microorganisms to clindamycin, which may cause superinfection. Allergic reactions.
SPECIAL INSTRUCTIONS Duac Gel:
Duakom treatment should be done with caution in patients with regional enteritis or ulcerative colitis, a history, or colitis associated with antibiotics in history. Also be used with caution in patients with atopic dermatitis, which may further dry the skin.
In the event of prolonged or significant diarrhea, or if the patient suffers from abdominal cramps, treatment Duac Gel should be stopped immediately, since these symptoms may indicate colitis, associated with antibiotics. Necessary to conduct appropriate diagnostic tests such as determination of Clostridium difficile and its toxin, and, if necessary, colonoscopy and review treatment options for colitis.
In some cases it may be necessary 4-6 weeks pre-treatment to achieve full therapeutic effect.
Avoid contact with the drug in the mouth, eyes, mucous membranes and eczematous skin. Apply gel for sensitive skin with caution. In case of accidental contact with eyes, rinse with plenty of water.
This product may discolor hair or colored fabrics.
Not recommended during treatment in the sun and other ultraviolet radiation under.
Use during pregnancy and lactation.
Security applications Duac Gel during pregnancy has not been established, so for this category of patients the drug is prescribed only when the benefits to the mother outweighs the potential risk to the fetus.
It has been reported on the penetration of clindamycin in breast milk after oral and parenteral administration. Therefore Duac Gel contraindicated use during breast-feeding.
Children. Do not use in children under the age of 12 years.
Ability to influence the reaction rate on driving or operating other machinery. No effect.
INTERACTION Duac Gel:
while the application of topical antibiotics, medicine, conventional or abrasive soaps and cosmetics that have DRYING effect, as well as funds with high concentrations of alcohol and / or binder may be a cumulative irritant effect. Particular caution comply with the application of drugs that contain substances that contribute to skin dryness (benzoyl peroxide).
You should avoid the simultaneous use Duac Gel and local drug treatment for acne that contain derivatives of vitamin A.
In the application of antibiotics alone may be cross-resistance with other antibiotics such as lincomycin and erythromycin.
There are potential synergies between clindamycin and gentamicin.
